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Black seed oil and blood sugar and type 2 diabetes: what the evidence says

Based on the evidence, black seed lowers blood sugar modestly, about half a point of HbA1c in pooled trials of people with type 2 diabetes or metabolic syndrome, though most trials were small and short.

4/5 Moderate

At least one well-run randomized trial in people on this outcome, with a positive result. How we score

Every meta-analysis we found, from 7 to 82 trials, reports lower fasting glucose and HbA1c (the three-month blood sugar average) with black seed: HbA1c about 0.45 to 0.7 points and fasting glucose about 10 to 21 mg/dL lower than in control groups. Insulin levels and insulin resistance mostly did not change.

Placebo-controlled trials are small: 43 and 50 people with type 2 diabetes for 8 weeks, 140 women with metabolic syndrome for 8 weeks. One older trial (123 people, powdered seed) found no significant difference. Head to head, black seed oil was worse than metformin in newly diagnosed diabetes and about equal to metformin or lifestyle change in prediabetes.

The honest weak points: heterogeneity between trials is very high (one analysis found I2 of 93-96%), most trials last 8 to 12 weeks, several are open-label or not truly randomized, and a 2025 umbrella review rated the reviews of black seed low to very low quality. Black seed did not reach the 'moderate certainty' group that ginger and turmeric reached in that review. No trial has tested whether it prevents diabetes complications.

Thymoquinone, black seed's best-known compound, has one human trial here: 50 or 100 mg tablets added to metformin lowered HbA1c by 0.4-0.5 points against 0.2 on metformin alone in 60 patients. That is a purified compound, not the oil.

If you take diabetes medicine, do not add black seed or swap a prescription for it without your doctor: the trials show it lowers blood sugar, so it may add to the effect of insulin or diabetes pills.

We screened all 66 human-study records PubMed returned and read 42 abstracts in full: 15 of the 28 systematic reviews (the others covered other herbs, animal studies or other outcomes) and all 27 trial records (one a protocol); the rest were surveys of herbal use, protocols or studies of other outcomes.

The evidence ladder higher rungs count for more
  1. Meta-analyses of trialspooled randomized trials9
  2. Human studiestrials and population studies16
  3. Case reportssingle people1
  4. Animal studiesmostly rodents180
  5. Lab studiescells, test tubes90

The studies in people, read one by one

ResultTypeWhat they didWhat they found
PositiveSystematic review / meta-analysis, 2026
2,145 people		Meta-analysis of 31 randomized trials in people with metabolic diseases, GRADE-assessed
Measured: Fasting glucose, HbA1c, insulin resistance, weight, blood pressure		Fasting glucose -18.62 mg/dL (95% CI -23.30 to -13.95), HbA1c -0.56 (-0.79 to -0.33); no effect on insulin or insulin resistance (HOMA-IR). PubMed 41858302
PositiveSystematic review / meta-analysis, 2025
5,026 people		Dose-response meta-analysis of 82 randomized trials (1 to 48 weeks, 200 to 4,600 mg a day), GRADE-assessed
Measured: Cardiovascular risk factors including fasting glucose, HbA1c, after-meal glucose		Reports significant improvements in fasting glucose, HbA1c and after-meal glucose among more than 30 outcomes; the abstract gives no effect sizes or certainty ratings. PubMed 40714301
PositiveSystematic review / meta-analysis, 2025Meta-analysis of 16 randomized trials in type 2 diabetes
Measured: Fasting glucose, HbA1c, insulin, lipids, weight		Fasting glucose -21.43 mg/dL (p = 0.005), HbA1c -0.44 (p = 0.01); no significant change in after-meal glucose, insulin, HOMA, triglycerides or weight. PubMed 40210172
PositiveSystematic review / meta-analysis, 2024Meta-analysis of 30 randomized trials in adults
Measured: Fasting glucose, HbA1c, insulin, HOMA-IR		Fasting glucose and HbA1c fell (standardized differences -1.71 and -2.16) but heterogeneity was extreme (I2 93-96%); no effect on insulin or HOMA-IR. PubMed 39181437
PositiveSystematic review / meta-analysis, 2025Meta-analysis of 7 randomized trials in metabolic syndrome
Measured: Lipids, fasting glucose, HbA1c		Fasting glucose (standardized difference -0.8) and HbA1c (-0.37) fell; the authors found no publication bias. PubMed 38265398
PositiveSystematic review / meta-analysis, 2020Meta-analysis of 50 trials
Measured: Glucose, HbA1c, lipids, inflammation		Fasting glucose -15.18 mg/dL (95% CI -19.82 to -10.55), HbA1c -0.45 (-0.66 to -0.23); CRP and TNF-alpha did not change significantly. PubMed 32394508
PositiveSystematic review / meta-analysis, 2019Meta-analysis of 17 randomized trials
Measured: Fasting and after-meal glucose, HbA1c		Fasting glucose -9.93 mg/dL, after-meal glucose -14.79 mg/dL, HbA1c -0.57%; oil worked better than powder on fasting glucose. PubMed 30873688
PositiveSystematic review / meta-analysis, 2017Meta-analysis of 7 trials in type 2 diabetes
Measured: Fasting glucose, HbA1c, lipids		Fasting glucose -17.84 mg/dL, HbA1c -0.71%, total and LDL cholesterol lower; triglycerides rose with seed powder but fell with oil. PubMed 29154069
MixedSystematic review / meta-analysis, 2025Umbrella review of 8 meta-analyses and 2 systematic reviews of herbal medicines in type 2 diabetes
Measured: HbA1c, insulin resistance, quality of the evidence		Black seed was among herbs that improved insulin-resistance measures, but it was not among those with moderate-to-high certainty for HbA1c; review quality was low to very low. PubMed 41029669
PositiveSystematic review / meta-analysis, 2022Systematic review of 17 clinical studies (16 of the seed or oil, 1 of thymoquinone)
Measured: Glucose, HbA1c, insulin resistance, beta-cell function		Seed preparations improved fasting and after-meal glucose, HbA1c and insulin resistance against placebo; thymoquinone with metformin lowered HbA1c more than metformin alone (one trial). PubMed 36292966
PositiveSystematic review / meta-analysis, 2024
701 people		Systematic review of randomized trials in metabolic syndrome, 2011-2021
Measured: Glycaemic indices, lipids, blood pressure		5 of 7 trials reported a significant fall in glycaemic measures; only 1 of 5 improved blood pressure. PubMed 39002164
PositiveRandomized trial, 2021
43 people		Randomized, double-blind, placebo-controlled (sunflower oil); 1 g oil a day for 8 weeks, type 2 diabetes
Measured: Fasting glucose, HbA1c, HOMA-IR, lipids, blood pressure		Fasting glucose (p = .03) and HbA1c (p = .001) fell more than on placebo; insulin resistance (HOMA-IR) did not change (p = .51). PubMed 34142392
PositiveRandomized trial, 2020
50 people		Double-blind randomized trial; 1 g oil a day for 8 weeks vs placebo, type 2 diabetes
Measured: Fasting glucose, lipids, CRP		Fasting glucose, triglycerides and LDL fell and HDL rose compared with placebo (all p < .001). PubMed 32510754
PositiveRandomized trial, 2020
140 people		Randomized, double-blind, placebo-controlled; 500 mg a day for 8 weeks, postmenopausal women with metabolic syndrome
Measured: Fasting glucose, HbA1c, lipids, weight		Fasting glucose 90.8 vs 113.7 mg/dL on placebo after 8 weeks (p < 0.001); LDL and triglycerides also lower. PubMed 32236818
PositiveRandomized trial, 2019
50 people		Randomized, double-blind, placebo-controlled; 2 g a day plus lifestyle change for 12 weeks, fatty liver disease
Measured: Glucose, insulin, insulin resistance, liver fat		Glucose -7.95 vs -1.22 on placebo (p = .041), insulin and HOMA-IR also improved; liver fat fell more (p = .005). PubMed 31293021
PositiveRandomized trial, 2026
60 people		Randomized, double-blind, placebo-controlled; 1 g oil a day for 12 weeks, polycystic ovary syndrome
Measured: Fasting glucose, insulin, IL-6		Fasting glucose -8.16 mg/dL vs placebo (95% CI -12.73 to -3.58); no difference in insulin, HOMA-IR or testosterone. PubMed 42601227
PositiveRandomized trial, 2015
250 people		Double-blind randomized trial of black seed 1.5 g/day, turmeric, both, or placebo for 8 weeks, men with metabolic syndrome (Karachi)
Measured: Fasting glucose, lipids, body fat, CRP		At 8 weeks black seed lowered lipids and fasting glucose compared with placebo; the low-dose combination with turmeric improved most measures. PubMed 25847554
PositiveRandomized trial, 2021
60 people		Randomized, 3 arms for 90 days: metformin alone or metformin plus 50 or 100 mg thymoquinone tablets, type 2 diabetes (thymoquinone, not the seed)
Measured: HbA1c, fasting and after-meal glucose		HbA1c went from 7.2 to 6.7 and 6.8 with thymoquinone vs 7.3 to 7.1 on metformin alone, among patients who completed the study. PubMed 33684953
PositiveRandomized trial, 2010
94 people		Randomized to 1, 2 or 3 g seed capsules a day for 12 weeks on top of diabetes pills; no placebo group (Saudi Arabia)
Measured: Fasting and after-meal glucose, HbA1c		At 2 g/day HbA1c fell 1.52% from baseline (P < 0.0001); 1 g/day was not significant and 3 g/day added nothing. PubMed 21675032
PositiveClinical trial, 2015
114 people		Assigned 'by convenience' (not randomized) to 2 g seed a day or charcoal placebo for one year, type 2 diabetes on tablets
Measured: Fasting glucose, HbA1c, oxidative stress		HbA1c went from 8.6 to 8.2 on black seed and from 8.2 to 8.5 on placebo; fasting glucose 195 to 172 vs 180 to 180. PubMed 25706772
MixedRandomized trial, 2019Open-label randomized trial, 1,350 mg oil a day vs metformin for 3 months, newly diagnosed type 2 diabetes (Egypt)
Measured: Fasting and after-meal glucose, HbA1c, weight		Black seed oil was inferior to metformin at lowering fasting and after-meal glucose and HbA1c, but similar for weight and waist. PubMed 31152309
No effectRandomized trial, 2021
117 people		Randomized: oil 450 mg twice daily vs metformin vs lifestyle change for 6 months, obese adults with prediabetes
Measured: Glucose measures, weight, lipids, inflammation		Black seed was statistically similar to metformin and to lifestyle change on most glucose measures; it lowered lipids and TNF-alpha more. PubMed 34006388
No effectRandomized trial, 2009
123 people		Randomized, double-blind, placebo-controlled, powdered seed capsules, adults (Karachi)
Measured: Blood sugar, lipids, blood pressure, weight		Favourable changes on almost all measures were not statistically significant; 73 of 123 completed the study. PubMed 19500003
MixedRandomized trial, 2021
60 people		Randomized, double-blind; 2 g oil vs sunflower oil for 8 weeks, coronary artery disease
Measured: Fasting glucose, weight, blood pressure		Fasting glucose -4.32 mg/dL vs placebo, but the reported confidence interval (-0.51 to 9.15) crosses zero; weight and blood pressure fell. PubMed 33851461
PositiveRandomized trial, 2025
116 people		Randomized: 1 g extract a day vs medroxyprogesterone for 16 weeks, adolescent girls with polycystic ovary syndrome (secondary analysis)
Measured: Fasting and 2-hour glucose		Fasting glucose (p = 0.004) and 2-hour glucose (p = 0.023) fell more with black seed than in the hormone-treated control group. PubMed 40055705
PositiveRandomized trial, 2017Open-label randomized trial, 2.5 mL oil a day for 12 weeks with usual care, diabetic kidney disease stage 3-4
Measured: Blood glucose, kidney function		Blood glucose, creatinine, urea and urine protein fell compared with control; the abstract gives no numbers. PubMed 28098097
PositiveClinical trial, 2020
40 people		Uncontrolled 12-week study of chapatis with black seed and fenugreek (5.45 g/day), overweight and type 2 diabetes
Measured: HbA1c, glucose, weight, lipids		HbA1c, fasting and 2-hour glucose and weight fell from baseline (P < .05); fenugreek given at the same time. PubMed 32758056
NegativeCase report, 2013
1 people		Case report (no abstract in PubMed)
Measured: Kidney function		Title reports acute kidney failure associated with black seed in a patient with diabetes. PubMed 23464648

Where the sources agree, and where they don’t

3 of 7 kinds of source point toward a benefit, 0 toward no effect or harm, 2 are mixed, and 2 have no data yet. Agreement between independent kinds of evidence matters more than the number of papers in any one of them.

Kind of sourcePoints toDetail
Meta-analyses of trialsPositiveHbA1c about 0.45-0.7 lower; very high heterogeneity
Placebo-controlled trialsPositive43 to 140 people, 8-12 weeks
Head-to-head with metforminMixedworse in new diabetes; similar in prediabetes
Thymoquinone tablets (60 people)PositiveHbA1c 0.4-0.5 down vs 0.2 on metformin alone
Registered trialsNo data6 finished or stalled trials with no results, one 253 women
FDA reportsNo datano blood-sugar reports among 25
Public reportsMixed2 helped, 1 no effect, 1 too early

Beyond Google: 13 findings about Black seed oil from trial registries, FDA reports and patent offices that a normal search rarely shows. See them

What people report

We read public first-person posts and counted every outcome, good or bad. 4 reports about this condition, read on 2026-10-28; 0 mention side effects.

  • 2Helped
  • 1No effect
  • 0Got worse
  • 0Mixed
  • 1Too early

Why these counts prove nothing on their own: people who post are not a random sample, most take other treatments at the same time, and nobody checks the diagnosis. We show them because they tell researchers what to test next.

Read all 4 reports
  • Too early After a first 1,500 mg dose of oil, one fasting reading came in lower than usual; seed powder taken earlier had disappointed. Diabetes Daily forum, 2016-01-06 (A single glucose reading after one dose.)
  • Helped Taking black seed since 2012 with sesame and chia; reports no metformin, HbA1c 5.4, normal cholesterol, weight loss and fewer allergy pills. WebMD user reviews, 2021-05-29 (Several seeds and probably diet changes together; no before values given; stopping metformin is the poster's own account.)
  • Helped In the first week of gel caps, joint pain and inflammation eased and glucose fell enough to lower insulin doses. WebMD user reviews, 2019-12-03 (Only one week; insulin changes self-made; low blood sugar is a risk when combined with insulin.)
  • No effect Nearly five months of oil brought no weight loss, and blood sugar went up over the same period. WebMD user reviews, 2020-04-22 (Review text is cut off; it does not say the rise was caused by black seed.)

Every other paper we found

PubMed returned 418 papers for this search on 2026-10-28. We read the human studies above ourselves. The rest are sorted by type automatically from PubMed's labels, which are sometimes wrong. We removed 38 papers that only share a word with this search (reviews of other herbs, animal-only reviews, trial protocols, surveys of herbal use, and mixtures of six herbs).

Animal studies 180
  1. Combined Supplementation With Trigonella foenum-graecum and Nigella sativa Seed Powders Improves Glycemic Control, Dyslipidemia, and Organ Function in Alloxan-Induced Diabetic Rats. J Food Sci, 2026
  2. Dual antibacterial and pro-healing effects of thymoquinone in an experimental infected diabetic wound model. BMC Complement Med Ther, 2026
  3. Combining glycine with thymoquinone offers a promising strategy for diabetes treatment. Sci Rep, 2026
  4. Multifunctional bilayered nanofibrous scaffold of chitosan/poly(caprolactone) enriched with simvastatin and thymoquinone for accelerated diabetic wound healing. Int J Biol Macromol, 2026
  5. Green synthesis of magnesium oxide nanoparticles using Nigella sativa seed extract: characterization, in vitro antioxidant activities, and wound healing efficacy in streptozotocin-induced diabetic rats. RSC Adv, 2026
  6. Protective effects of BAIBA and thymoquinone in type 1 diabetic nephropathy: modulation of Irisin, NF-κB, and Caspase-3 expression. J Mol Histol, 2026
  7. IQ-RKT Formulation mitigates cardiomyocytes injury by targeting AGEs-RAGE-ROS-dependent TRAF3IP2/JNK apoptotic nexus in diabetes. Free Radic Biol Med, 2026
  8. Effects of thymoquinone on cognitive functions and kynurenine metabolites induced in rats by streptozotocin/nicotinamide. Eur J Pharmacol, 2026
  9. Optimized renal protection with combined thymoquinone and glycine treatment: synergistic management of streptozotocin-induced nephropathy. Naunyn Schmiedebergs Arch Pharmacol, 2026
  10. Functional-Diet Potential of Black Cumin-Enriched Acha-Based Cookies on Plasmodium berghei-Infected Diabetic Mice. J Med Food, 2026
  11. Does Zn-Mediated Regulation of the Kynurenine Pathway Provide the Link Between Periodontal Disease and Diabetes? Biol Trace Elem Res, 2026
  12. The protective effects of thymoquinone against tartrazine-induced pancreatic injury and its impact on oxidative stress, caspase 3, blood glucose, insulin and cholesterol levels. Arch Physiol Biochem, 2026
  13. Insulinotropic and anti-obesity properties of ethno-medicinal plants: pharmacology-based and in-silico predictions. Nat Prod Res, 2026
  14. Fluoxetine as an antidepressant agent induces directly deleterious effects on rat isolated pancreatic mitochondria: ameliorative role of betanin. Xenobiotica, 2025
  15. Formulation and evaluation of safe and effective polyherbal antidiabetic drug. Pak J Pharm Sci, 2025
  16. Thymoquinone controlled obesity and invigorated cognitive and memory performance in rats consuming a high-fat diet via modulating oxidative stress, inflammation and apoptosis. Sci Rep, 2025
  17. Niosomes for enhanced oral delivery of pioglitazone: in vitro characterization and in vivo evaluation. J Pharm Pharmacol, 2025
  18. Black seed oil boosts antidiabetic activity of glibenclamide: development of solidified self nanoemulsifying drug delivery system and evaluation in Streptozotocin-Induced diabetic rat model. Pharm Dev Technol, 2025
  19. Exploring the antidiabetic effect of various therapeutic essential oils synergistically with repaglinide. J Pharm Sci, 2025
  20. Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats. Antioxidants (Basel), 2025
  21. Thymoquinone Mediates Müller Cell Apoptosis via miR-29b/SP1 Pathway: A Potential Therapeutic Approach in Diabetic Retinopathy. Drug Res (Stuttg), 2025
  22. Phytochemical Profiling and Biological Activities of Nigella sativa Vinegar Extract: An Insight Into Hypoglycemic Potential Using In Vivo and In Silico Studies. Chem Biodivers, 2025
  23. Cadmium-induced pancreatic toxicity in rats: comparing vitamin C and Nigella sativa as protective agents: a histomorphometric and ultrastructural study. Toxicol Mech Methods, 2025
  24. UV-spectrophotometric and spectroscopic observed Vachellia nilotica and Nigella sativa formulations regularized the histopathological and biochemical parameters during wound contraction. Microsc Res Tech, 2025
  25. Water in nigella oil microemulsion for enhanced oral bioavailability of linagliptin. Drug Deliv Transl Res, 2025
  26. Anti-inflammatory, antidiabetic and hypolipidemic potential of Cinnamomum verum J. Presi bark coupled with FT-IR and HPLC analysis. Pak J Pharm Sci, 2024
  27. Therapeutic Effects of Nigella sativa Oil and Whole Seeds on STZ-Induced Diabetic Rats: A Biochemical and Immunohistochemical Study. Oxid Med Cell Longev, 2024
  28. Prevention of Chronic Diabetic Neuropathy and Diabetes-Associated Cognitive Impairment Using Medicinal Herbs (Cassia Angustifolia and Nigella Sativa). Yale J Biol Med, 2024
  29. Nutraceutical activities of Trigonella foenum-graecum and Nigella sativa seeds in the management of diabetes-induced in albino rats. J Food Sci, 2024
  30. Thymoquinone attenuates diabetes-induced hepatic damage in rat via regulation of oxidative/nitrosative stress, apoptosis, and inflammatory cascade with molecular docking approach. Sci Rep, 2024
  31. Effect of thymoquinone on acetic acid-induced visceral nociception in rats: role of central cannabinoid and α2-adrenergic receptors. Vet Res Forum, 2024
  32. Polyherbal extract improves glycometabolic control in alloxan-induced diabetic rats via down-regulating the MAPK/JNK pathway, modulating Nrf-2/Keap-1 expression, and stimulating insulin signaling. Iran J Basic Med Sci, 2024
  33. Thymoquinone mitigates obesity and diabetic parameters through regulation of major adipokines, key lipid metabolizing enzymes and AMPK/p-AMPK in diet-induced obese rats. 3 Biotech, 2024
  34. The Natural Protoalkaloid Methyl-2-Amino-3-Methoxybenzoate (MAM) Alleviates Positive as well as Cognitive Symptoms in Rat and Mouse Schizophrenia Models. Curr Neuropharmacol, 2024
  35. Impact of Gestational Diabetes on the Thymus Gland of Rat's Offspring and the Possible Ameliorating Effect of Thymoquinone: Biochemical, Histological, and Immunohistochemical Study. Microsc Microanal, 2023
  36. Thymoquinone attenuates olanzapine-induced metabolic disorders in rats. Mol Biol Rep, 2023
  37. Antioxidant, Hypoglycemic, Antilipidemic, and Protective Effect of Polyherbal Emulsion (F6-SMONSECCE) on Alloxan-Induced Diabetic Rats. ACS Omega, 2023
  38. Antimicrobial activity and wound healing effect of a novel natural ointment: an in vitro and in vivo study. J Wound Care, 2023
  39. Efficacy Confirmation Test of Black Cumin (Nigella sativa L.) Seeds Extract Using a High-Fat Diet Mouse Model. Metabolites, 2023
  40. Studying the actions of sage and thymoquinone combination on metabolic syndrome induced by high-fat diet in rats. Eur Rev Med Pharmacol Sci, 2023
  41. Comparison of the anti-diabetic and nephroprotective activities of vitamin E, metformin, and Nigella sativa oil on kidney in experimental diabetic rats. Iran J Basic Med Sci, 2023
  42. Renoprotective Effect of Thymoquinone against Streptozotocin-Induced Diabetic Nephropathy: Role of NOX2 and Nrf2 Signals. Curr Mol Pharmacol, 2023
  43. Protective Effect of Nigella sativa Seed Extract and its Bioactive Compound Thymoquinone on Streptozotocin-induced Diabetic Rats. Cardiovasc Hematol Agents Med Chem, 2023
  44. Thymoquinone-treated mouse mesenchymal stem cells-derived conditioned medium inhibits human breast cancer cells in vitro. Chem Biol Interact, 2023
  45. Thymoquinone Attenuates Retinal Expression of Mediators and Markers of Neurodegeneration in a Diabetic Animal Model. Curr Mol Pharmacol, 2023
  46. Thymoquinone activates imidazoline receptor to enhance glucagon-like peptide-1 secretion in diabetic rats. Arch Med Sci, 2023
  47. Comparative study of hypoglycaemic and antioxidant potential of methanolic seed extract and oil of Nigella sativa on alloxanized diabetic rabbits. Pak J Pharm Sci, 2022
  48. Novel Black Seed Polysaccharide Extract-g-Poly (Acrylate) pH-Responsive Hydrogel Nanocomposites for Safe Oral Insulin Delivery: Development, In Vitro, In Vivo and Toxicological Evaluation. Pharmaceutics, 2022
  49. Biological and Hypoglycemic Effects of a Polyherbal Extract on Alloxanized Diabetic Rats. ACS Omega, 2022
  50. Influences of Glimepiride Self-Nanoemulsifying Drug Delivery System Loaded Liquisolid Tablets on the Hypoglycemic Activity and Pancreatic Histopathological Changes in Streptozotocin-Induced Hyperglycemic Rats. Nanomaterials (Basel), 2022
  51. An investigation of correlation between structural and functional properties of Nigella sativa protein isolate. J Food Biochem, 2022
  52. Effect of hydroalcoholic seed extract of Nigella sativa on hepatic and pancreatic factors of Nrf2 and FGF21 in the regulation of insulin transcription factors of MafA and PDX-1 in streptozotocin-treated diabetic rats. Nutr Metab (Lond), 2022
  53. Therapeutic significance of thymoquinone-loaded chitosan nanoparticles on streptozotocin/nicotinamide-induced diabetic rats: In vitro and in vivo functional analysis. Int J Biol Macromol, 2022
  54. Co-delivery of gentiopicroside and thymoquinone using electrospun m-PEG/PVP nanofibers: In-vitro and In vivo studies for antibacterial wound dressing in diabetic rats. Int J Pharm, 2022
  55. Effects of black cumin seed oil on oxidative stress and expression of membrane-cytoskeleton linker proteins, radixin, and moesin in streptozotocin-induced diabetic rat liver. Hepatol Forum, 2022
  56. Formulation and Evaluation of Topical Linezolid Nanoemulsion for Open Incision Wound in Diabetic Animal Model. AAPS PharmSciTech, 2022
  57. Hepato-protective effects of thymoquinone and beta-aminoisobutyric acid in streptozocin induced diabetic rats. Biotech Histochem, 2022
  58. Standardization of Berberis aristata DC and Nigella sativa L. Using HPTLC and GCMS and Their Antineoplasia Activity in 7,12-Dimethylbenz[a]anthracene-Induced Mouse Models. Front Pharmacol, 2021
  59. Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats. Iran J Basic Med Sci, 2021
  60. Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats. Biopharm Drug Dispos, 2021
  61. Chemical Composition Analysis Using HPLC-UV/GC-MS and Inhibitory Activity of Different Nigella sativa Fractions on Pancreatic α-Amylase and Intestinal Glucose Absorption. Biomed Res Int, 2021
  62. Thymoquinone Preserves Pancreatic Islets Structure Through Upregulation of Pancreatic β-Catenin in Hypothyroid Rats. Diabetes Metab Syndr Obes, 2021
  63. The ameliorative effects of thymoquinone and beta-aminoisobutyric acid on streptozotocin-induced diabetic cardiomyopathy. Tissue Cell, 2021
  64. Effect of thymoquinone on high fat diet and STZ-induced experimental type 2 diabetes: A mechanistic insight by in vivo and in silico studies. J Food Biochem, 2021
  65. Effect of Nigella sativa, atorvastatin, or L-Carnitine on high fat diet-induced obesity in adult male Albino rats. Biomed Pharmacother, 2021
  66. Acute effect of thymoquinone on action potential and ionic currents of rat cardiac myocytes. Bratisl Lek Listy, 2021
  67. Thymoquinone Lowers Blood Glucose and Reduces Oxidative Stress in a Rat Model of Diabetes. Molecules, 2021
  68. Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway. J Food Biochem, 2021
  69. Protective roles of thymoquinone and vildagliptin in manganese-induced nephrotoxicity in adult albino rats. Environ Sci Pollut Res Int, 2021
  70. Development and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus. Drug Deliv, 2021
  71. The Effect of Nigella Sativa on Renal Oxidative Injury in Diabetic Rats. Saudi J Kidney Dis Transpl, 2020
  72. Effects of Nigella sativa seed polysaccharides on type 2 diabetic mice and gut microbiota. Int J Biol Macromol, 2020
  73. Potential preventive and protective perspectives of different spice powders and their mixtures in rat model. Lipids Health Dis, 2020
  74. Effects of Thymoquinone on Small-Molecule Metabolites in a Rat Model of Cerebral Ischemia Reperfusion Injury Assessed using MALDI-MSI. Metabolites, 2020
  75. PROTECTIVE EFFECT OF NIGELLA SATIVA OIL ON MYOCARDIUM IN STREPTOZOTOCIN-INDUCED DIABETIC RATS. Acta Endocrinol (Buchar), 2019
  76. The effects of natural nano-sized clinoptilolite and Nigella sativa supplementation on serum bone markers in diabetic rats. Bioimpacts, 2019
  77. Nigella sativa stimulates insulin secretion from isolated rat islets and inhibits the digestion and absorption of (CH2O)n in the gut. Biosci Rep, 2019
  78. GLP-1 mediates the modulating effect of thymoquinone on feeding behaviors in diabetic rats. Diabetes Metab Syndr Obes, 2019
  79. Antidiabetic activity enhancement in streptozotocin + nicotinamide-induced diabetic rats through combinational polymeric nanoformulation. Int J Nanomedicine, 2019
  80. Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes. Biotech Histochem, 2019
  81. Effect of Hydroethanolic Extract of Nigella sativa L. on Skin Wound Healing Process in Diabetic Male Rats. Int J Prev Med, 2019
  82. The possible protective effects of virgin olive oil and Nigella sativa seeds on the biochemical and histopathological changes in pancreas of hyperlipidaemic rats. Folia Morphol (Warsz), 2019
  83. Nigella sativa L. seed regulated eNOS, VCAM-1 and LOX-1 genes expression and improved vasoreactivity in aorta of diabetic rat. J Ethnopharmacol, 2019
  84. Thymoquinone and fluoxetine alleviate depression via attenuating oxidative damage and inflammatory markers in type-2 diabetic rats. Arch Physiol Biochem, 2019
  85. Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice. PLoS One, 2018
  86. Thymoquinone Attenuates Cardiomyopathy in Streptozotocin-Treated Diabetic Rats. Oxid Med Cell Longev, 2018
  87. Effects of dexmedetomidine and thymoquinone on erythrocyte deformability in lower limb ischemia reperfusion injury in streptozotocin-induced diabetic rats. Bratisl Lek Listy, 2018
  88. Impact of thymoquinone on cyclosporine A pharmacokinetics and toxicity in rodents. J Pharm Pharmacol, 2018
  89. Thymoquinone ameliorates some endocrine parameters and histological alteration in a rat model of polycystic ovary syndrome. Int J Reprod Biomed, 2018
  90. MicroRNA-146a: A Comprehensive Indicator of Inflammation and Oxidative Stress Status Induced in the Brain of Chronic T2DM Rats. Front Pharmacol, 2018
  91. A Comparative Study of the Effects of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats. J Evid Based Integr Med, 2018
  92. Black Seed Thymoquinone Improved Insulin Secretion, Hepatic Glycogen Storage, and Oxidative Stress in Streptozotocin-Induced Diabetic Male Wistar Rats. Oxid Med Cell Longev, 2018
  93. Improvement of antihyperglycemic activity of nano-thymoquinone in rat model of type-2 diabetes. Chem Biol Interact, 2018
  94. Thymoquinone Can Improve Neuronal Survival and Promote Neurogenesis in Rat Hippocampal Neurons. Mol Nutr Food Res, 2018
  95. Pharmacotherapy with Thymoquinone Improved Pancreatic β-Cell Integrity and Functional Activity, Enhanced Islets Revascularization, and Alleviated Metabolic and Hepato-Renal Disturbances in Streptozotocin-Induced Diabetes in Rats. Pharmacology, 2018
  96. In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of Nigella sativa. Evid Based Complement Alternat Med, 2017
  97. The protective effect of thymoquinone over olanzapine-induced side effects in liver, and metabolic side effects. Bratisl Lek Listy, 2017
  98. Effects of separate and concurrent supplementation of Nano-sized clinoptilolite and Nigella sativa on oxidative stress, anti-oxidative parameters and body weight in rats with type 2 diabetes. Biomed Pharmacother, 2017
  99. The Effect of Thymoquinone on Nuclear Factor Kappa B Levels and Oxidative DNA Damage on Experimental Diabetic Rats. Pharmacogn Mag, 2017
  100. Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways. PLoS One, 2017
  101. Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats. Chem Biol Interact, 2017
  102. Studies on antihyperlipidemic and endothelium modulatory activities of polyherbal formulation (POL4) and its ingredients in high fat diet-fed rats. Pak J Pharm Sci, 2017
  103. Oxidative stress and expression of insulin signaling proteins in the brain of diabetic rats: Role of Nigella sativa oil and antidiabetic drugs. PLoS One, 2017
  104. Thymoquinone Defeats Diabetes-Induced Testicular Damage in Rats Targeting Antioxidant, Inflammatory and Aromatase Expression. Int J Mol Sci, 2017
  105. GC-MS-based Metabolomic Profiling of Thymoquinone in Streptozotocin-induced Diabetic Nephropathy in Rats. Nat Prod Commun, 2017
  106. The Antidiabetic Activity of Nigella sativa and Propolis on Streptozotocin-Induced Diabetes and Diabetic Nephropathy in Male Rats. Evid Based Complement Alternat Med, 2017
  107. Pharmacological basis for the medicinal use of polyherbal formulation and its ingredients in cardiovascular disorders using rodents. BMC Complement Altern Med, 2017
  108. Anti-diabetic effect of three new norditerpenoid alkaloids in vitro and potential mechanism via PI3K/Akt signaling pathway. Biomed Pharmacother, 2017
  109. Retraction note: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation. Diagn Pathol, 2016
  110. Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet. Oxid Med Cell Longev, 2016
  111. Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation. Sci Rep, 2016
  112. Nigella sativa oil and thymoquinone ameliorate albuminuria and renal extracellular matrix accumulation in the experimental diabetic rats. Eur Rev Med Pharmacol Sci, 2016
  113. Minimization of the Risk of Diabetic Microangiopathy in Rats by Nigella sativa. Pharmacogn Mag, 2016
  114. Nigella sativa seed decreases endothelial dysfunction in streptozotocin-induced diabetic rat aorta. Avicenna J Phytomed, 2016
  115. Thymoquinone Inhibits Angiotensin II-Induced Proliferation and Migration of Vascular Smooth Muscle Cells Through the AMPK/PPARγ/PGC-1α Pathway. DNA Cell Biol, 2016
  116. Effect of lipid extracts of Nigella sativa L. seeds on the liver ATP reduction and alpha-glucosidase inhibition. Pak J Pharm Sci, 2016
  117. Protective effect of thymoquinone improves cardiovascular function, and attenuates oxidative stress, inflammation and apoptosis by mediating the PI3K/Akt pathway in diabetic rats. Mol Med Rep, 2016
  118. Thymoquinone, a bioactive component of Nigella sativa, normalizes insulin secretion from pancreatic β-cells under glucose overload via regulation of malonyl-CoA. Am J Physiol Endocrinol Metab, 2016
  119. Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis. Naunyn Schmiedebergs Arch Pharmacol, 2016
  120. Effects of Nigella sativa L. seed oil on intima-media thickness and Bax and Caspase 3 expression in diabetic rat aorta. Anatol J Cardiol, 2016
  121. Ameliorative effects of thymoquinone against eye lens changes in streptozotocin diabetic rats. Environ Toxicol Pharmacol, 2015
  122. The effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in hippocampus of STZ-induced diabetic rats. Avicenna J Phytomed, 2015
  123. Effects of Thymoquinone on the Pharmacokinetics and Pharmacodynamics of Glibenclamide in a Rat Model. Nat Prod Commun, 2015
  124. Nigella sativa fixed and essential oil improves antioxidant status through modulation of antioxidant enzymes and immunity. Pak J Pharm Sci, 2015
  125. Effects of fenugreek, Nigella, and termis seeds in nonalcoholic fatty liver in obese diabetic albino rats. Arab J Gastroenterol, 2015
  126. Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats. J Cardiovasc Pharmacol, 2015
  127. Protective effect of thymoquinone against high-fructose diet-induced metabolic syndrome in rats. Eur J Nutr, 2015
  128. Potential protective effects of Nigella sativa and Allium sativum against fructose-induced metabolic syndrome in rats. J Oleo Sci, 2014
  129. Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus. BMC Complement Altern Med, 2014
  130. A structural study on the protection of glycation of superoxide dismutase by thymoquinone. Int J Biol Macromol, 2014
  131. A study of antioxidant activity, enzymatic inhibition and in vitro toxicity of selected traditional Sudanese plants with anti-diabetic potential. BMC Complement Altern Med, 2014
  132. Protective effect of thymoquinone on glucose or methylglyoxal-induced glycation of superoxide dismutase. Int J Biol Macromol, 2014
  133. Effects of thymoquinone on STZ-induced diabetic nephropathy: an immunohistochemical study. Ultrastruct Pathol, 2014
  134. Antihyperlipidemic effect of a polyherbal mixture in streptozotocin-induced diabetic rats. J Lipids, 2013
  135. Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation. Diagn Pathol, 2013
  136. Maternal supplementation of diabetic mice with thymoquinone protects their offspring from abnormal obesity and diabetes by modulating their lipid profile and free radical production and restoring lymphocyte proliferation via PI3K/AKT signaling. Lipids Health Dis, 2013
  137. Nigella sativa and thymoquinone suppress cyclooxygenase-2 and oxidative stress in pancreatic tissue of streptozotocin-induced diabetic rats. Pancreas, 2013
  138. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats. Adv Pharmacol Sci, 2012
  139. Thymoquinone and proanthocyanidin attenuation of diabetic nephropathy in rats. Eur Rev Med Pharmacol Sci, 2012
  140. Restoration of renal hemodynamics and functions during black cumin (Nigella sativa) administration in streptozotocin-induced diabetic rats. J Exp Pharmacol, 2012
  141. Immunomodulatory effects of black seeds and garlic on alloxan-induced Diabetes in albino rat. Allergol Immunopathol (Madr), 2012
  142. Ayurvedic formulation of Liv-Pro-08 reduces nonalcoholic fatty liver disease in rats fed with high-fat diet. J Acupunct Meridian Stud, 2011
  143. Effect of Thymoquinone on Oxidative Stress in Escherichia coli-Induced Pyelonephritis in Rats. Curr Ther Res Clin Exp, 2011
  144. Hypoglycemic effect of lipoic Acid, carnitine and nigella sativa in diabetic rat model. Int J Health Sci (Qassim), 2011
  145. The In Vivo Antidiabetic Activity of Nigella sativa Is Mediated through Activation of the AMPK Pathway and Increased Muscle Glut4 Content. Evid Based Complement Alternat Med, 2011
  146. Thymoquinone ameliorates chemical induced oxidative stress and β-cell damage in experimental hyperglycemic rats. Chem Biol Interact, 2011
  147. Perinatal supplementation with thymoquinone improves diabetic complications and T cell immune responses in rat offspring. Cell Immunol, 2011
  148. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. J Diabetes, 2010
  149. Attenuation of high cholesterol-induced oxidative stress in rabbit liver by thymoquinone. Eur J Gastroenterol Hepatol, 2010
  150. Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Res Vet Sci, 2010
  151. Protective effects of the volatile oil of Nigella sativa seeds on beta-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. J Mol Histol, 2009
  152. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Life Sci, 2009
  153. Effect of Carnitine and herbal mixture extract on obesity induced by high fat diet in rats. Diabetol Metab Syndr, 2009
  154. Effects of Nigella sativa oil and thymoquinone on oxidative stress and neuropathy in streptozotocin-induced diabetic rats. Pharmacology, 2009
  155. Protective effects of thymoquinone on streptozotocin-induced diabetic nephropathy. J Mol Histol, 2009
  156. Therapeutic effects of Nigella sativa on chronic HAART-induced hyperinsulinemia in rats. Can J Physiol Pharmacol, 2009
  157. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J Ethnopharmacol, 2009
  158. Effects of Nigella sativa and its major constituent, thymoquinone on sciatic nerves in experimental diabetic neuropathy. Neurochem Res, 2008
  159. Effect of thymoquinone on malformations and oxidative stress-induced diabetic mice. Pak J Biol Sci, 2007
  160. Effects of Nigella sativa and human parathyroid hormone on bone mass and strength in diabetic rats. Biol Trace Elem Res, 2007
  161. Combination therapy of Nigella sativa and human parathyroid hormone on bone mass, biomechanical behavior and structure in streptozotocin-induced diabetic rats. Acta Histochem, 2007
  162. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp Biol, 2006
  163. Thymoquinone reduces hepatic glucose production in diabetic hamsters. Res Vet Sci, 2005
  164. Macrophage-derived cytokine and nitric oxide profiles in type I and type II diabetes mellitus: effect of thymoquinone. Acta Diabetol, 2005
  165. Effects of Nigella unguicularis fixed oil on blood biochemistry and oxidant/antioxidant balance in rats. J Ethnopharmacol, 2005
  166. Successful abrogation by thymoquinone against induction of diabetes mellitus with streptozotocin via nitric oxide inhibitory mechanism. Int Immunopharmacol, 2005
  167. Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Fundam Clin Pharmacol, 2004
  168. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J Ethnopharmacol, 2004
  169. Effects of Nigella sativa on oxidative stress and beta-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol, 2004
  170. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet Sci, 2004
  171. Effects of sustained delivery of thymoqiunone on bone healing of male rats. Biomed Sci Instrum, 2004
  172. Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats. Tohoku J Exp Med, 2003
  173. Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster. Res Vet Sci, 2002
  174. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Planta Med, 2002
  175. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine, 2002
  176. Effect of Nigella sativa (Black Seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med, 2001
  177. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet Med A Physiol Pathol Clin Med, 2001
  178. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharm Belg, 1998
  179. The effect of a plants mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diabetes Res, 1991
  180. Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diabetol Lat, 1987
Lab studies 90
  1. Parallel bioassay-guided discovery and mechanistic characterization of a dual DPP-IV and ACE inhibitory peptide from defatted Nigella sativa seed cake. J Ethnopharmacol, 2026
  2. Evaluation of toll-like receptor inhibition by novel thymoquinone analogues as potential remedy for diabetic nephropathy. Mol Divers, 2026
  3. Herbal Medicine and Metabolic Syndrome: Phytochemicals Targeting the Molecular Causes of Insulin Resistance and Related Comorbidities. Curr Diabetes Rev, 2026
  4. [Role of spices in the management of diabetes and gestational diabetes]. Rev Med Suisse, 2026
  5. Inhibition of d-ribose-induced glycation of metalloprotein human myoglobin by bioactive quinones. Spectrochim Acta A Mol Biomol Spectrosc, 2026
  6. Multi-Omics and Machine Learning-Driven Discovery of ABCC8 (SUR1) for Diabetes Mellitus: Integrating Molecular Insights on Nigella sativa Bioactives and Sulfonylurea. Chem Biol Drug Des, 2026
  7. Salubrious effects of Ficus carica L. leaves extract in inflammation, diabetes, and obesity: An in-vitro, in-silico, and in-vivo study. Food Nutr Res, 2026
  8. Targeting AMPK/PI3K/AKT/mTOR pathway ameliorates kidney injury induced by type 2 diabetes. J Diabetes Metab Disord, 2026
  9. A sprayable TQ/Ce6@SAB/F-gel for accelerating wound healing via hypoxia-tolerant photodynamic therapy and immune-metabolic pathway. Biomaterials, 2026
  10. Synergistic delivery of 5-FU and thymoquinone via biogenic CaCO3 NPs in hyperglycemia-linked colorectal cancer cell. Ther Deliv, 2025
  11. Anticancer effects of thymoquinone on prostate cancer cells and natural killer cell activity. Oncol Lett, 2025
  12. Comment on "Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study". Paediatr Drugs, 2025
  13. Authors' Reply to Fatima Comment on "Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study". Paediatr Drugs, 2025
  14. Ethnobotanical survey of medicinal plants used in management of breast cancers in Qatar. Heliyon, 2025
  15. Preventive effects of thymoquinone on glyco-nitro-oxidized human fibrinogen: A comprehensive biophysical study projecting possible therapeutic role in diabetes and associated complications. Int J Biol Macromol, 2025
  16. Thymoquinone loaded nanoemulgel in streptozotocin induced diabetic wound. Nanomedicine (Lond), 2024
  17. Effects of dietary black cumin (Nigella sativa L.) meal on performance, blood metabolites, and digestibility in a rice straw-based diet of fattening Garut lambs. Vet World, 2024
  18. A wearable and stretchable dual-wavelength LED device for home care of chronic infected wounds. Nat Commun, 2024
  19. Monosaccharide-Mediated Glycoxidation of Bovine Serum Albumin and Its Prevention by Nigella sativa. ACS Omega, 2024
  20. Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease. World J Diabetes, 2024
  21. What's cooking? The normalization of meat in YouTube recipe videos consumed by South Asian British Muslims. Food Cult Soc, 2024
  22. Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses. Heliyon, 2024
  23. In vitro and functional investigation reveals the curative effect of thymoquinone from black cumin-loaded chitosan nanoparticles on streptozotocin induced paediatric diabetes. Regen Ther, 2024
  24. Network pharmacology and multitarget analysis of Nigella sativa in the management of diabetes and obesity: a computational study. J Biomol Struct Dyn, 2024
  25. The Efficacy of Nigella sativa L. and Curcumin Nanomicelle Alone or Together on Lipid Profile, Glycemic Control Indices, and Serum 17-Β Estradiol in Postmenopausal Women. J Caring Sci, 2023
  26. A descriptive survey study in endocrinology clinic: evaluation of the use of natural products. Curr Med Res Opin, 2023
  27. Protective effect of thymoquinone on glycation of human myoglobin induced by d-ribose. Int J Biol Macromol, 2023
  28. Green-synthesized nanoparticles of the polyherbal extract attenuate the necrosis of pancreatic β-cell in a streptozotocin-induced diabetic model. Heliyon, 2023
  29. Antioxidant Properties of Thymoquinone, Thymohydroquinone and Black Cumin (Nigella sativa L.) Seed Oil: Scavenging of Superoxide Radical Studied Using Cyclic Voltammetry, DFT and Single Crystal X-ray Diffraction. Antioxidants (Basel), 2023
  30. Effects of resistance training and nigella sativa on type 2 diabetes: implications for metabolic markers, low-grade inflammation and liver enzyme production. Arch Physiol Biochem, 2023
  31. A review on hypo-cholesterolemic activity of Nigella sativa seeds and its extracts. Bioinformation, 2022
  32. D-Ribose-Induced Glycation and Its Attenuation by the Aqueous Extract of Nigella sativa Seeds. Medicina (Kaunas), 2022
  33. The Prevalence and Pattern of Using Complementary and Alternative Medicine in Saudi Patients With Diabetes: A Cross-Sectional Study. Cureus, 2022
  34. Antibacterial Activity of Thymoquinone Against Shigella flexneri and Its Effect on Biofilm Formation. Foodborne Pathog Dis, 2022
  35. A Phase II, Randomized, Double-Blind, Double-Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of NW Low-Glu® in Patients Newly Diagnosed with Type 2 Diabetes Mellitus. Evid Based Complement Alternat Med, 2022
  36. Studying the Anticancer Effects of Thymoquinone on Breast Cancer Cells through Natural Killer Cell Activity. Biomed Res Int, 2022
  37. Effects of two triterpenoids from Nigella sativa seeds on insulin resistance of 3T3-L1 adipocytes. Front Nutr, 2022
  38. Development and Optimization of Nigella sativa Nanoemulsion Loaded with Pioglitazone for Hypoglycemic Effect. Polymers (Basel), 2022
  39. Chemical constituents from the seeds of Nigella glandulifera and their hypoglycemic activities. RSC Adv, 2022
  40. The effect of black seed (Nigella sativa) extract on lipid metabolism in HepG2 cells. Biochim Biophys Acta Mol Cell Biol Lipids, 2022
  41. Effect of Nigella Sativa Oil on Oxidative Stress, Inflammatory, and Glycemic Control Indices in Diabetic Hemodialysis Patients: A Randomized Double-Blind, Controlled Trial. Evid Based Complement Alternat Med, 2022
  42. Identification of novel anti-cancer agents, applying in silico method for SENP1 protease inhibition. J Biomol Struct Dyn, 2022
  43. Physical Activity and Natural Products and Minerals in the SARS-CoV-2 Pandemic: An Update. Ann Appl Sport Sci, 2021
  44. Virtual screening of functional foods and dissecting their roles in modulating gene functions to support post COVID-19 complications. J Food Biochem, 2021
  45. Phytochemical thymoquinone prevents hemoglobin glycoxidation and protofibrils formation: A biophysical aspect. Int J Biol Macromol, 2021
  46. Linking the Phytochemicals and the α-Glucosidase and α-Amylase Enzyme Inhibitory Effects of Nigella sativa Seed Extracts. Foods, 2021
  47. Prevalence of using herbs and natural products as a protective measure during the COVID-19 pandemic among the Saudi population: an online cross-sectional survey. Saudi Pharm J, 2021
  48. In silico Nigellidine (N. sativa) bind to viral spike/active-sites of ACE1/2, AT1/2 to prevent COVID-19 induced vaso-tumult/vascular-damage/comorbidity. Vascul Pharmacol, 2021
  49. Upsurge in autophagy, associated with mifepristone-treated polycystic ovarian condition, is reversed upon thymoquinone treatment. J Steroid Biochem Mol Biol, 2021
  50. Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment. J Biomol Struct Dyn, 2021
  51. Promising preventive and therapeutic effects of TaibUVID nutritional supplements for COVID-19 pandemic: towards better public prophylaxis and treatment (A retrospective study). Am J Blood Res, 2020
  52. Green synthesis of silver nanoparticles by Nigella sativa extract alleviates diabetic neuropathy through anti-inflammatory and antioxidant effects. Saudi J Biol Sci, 2020
  53. Concomitant Use of Herbal and Conventional Medicines among Patients with Diabetes Mellitus in Public Hospitals of Addis Ababa, Ethiopia: A Cross-Sectional Study. Evid Based Complement Alternat Med, 2020
  54. A New Oleanane Type Saponin from the Aerial Parts of Nigella sativa with Anti-Oxidant and Anti-Diabetic Potential. Molecules, 2020
  55. Reply to "Comment on: Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review". Int J Environ Res Public Health, 2020
  56. Comment on: Effects of Nigella Sativa on Type-2 Diabetes Mellitus: A Systematic Review. Int J Environ Res Public Health, 2020
  57. Investigation of total zinc contents and zinc-protein profile in medicinal plants traditionally used for diabetes treatment. Biometals, 2020
  58. Migration and Proliferation Effects of Thymoquinone-Loaded Nanostructured Lipid Carrier (TQ-NLC) and Thymoquinone (TQ) on In Vitro Wound Healing Models. Evid Based Complement Alternat Med, 2019
  59. Effects of Bread with Nigella Sativa on Blood Glucose, Blood Pressure and Anthropometric Indices in Patients with Metabolic Syndrome. Clin Nutr Res, 2019
  60. Comparing the efficacy of therapeutic packages in Persian Medicine with Classical Medicine in overweight patients: a randomized clinical trial. Electron Physician, 2018
  61. The association between quality of life and complementary and alternative medicine use in patients with diabetes mellitus. Complement Ther Clin Pract, 2018
  62. The utilization of nonprescription medications in Saudi patients with cardiovascular diseases. Saudi Pharm J, 2018
  63. Monitoring the protective ability of thymoquinone mixture with p-cymene against bovine serum albumin (BSA) glycation: MCR-ALS analysis based on combined spectroscopic and electrochemical methods. Int J Biol Macromol, 2018
  64. A nutraceutical combination of Cinnamomum cassia &Nigella sativa for Type 1 diabetes mellitus. J Ayurveda Integr Med, 2018
  65. Profile of Trace Elements in Selected Medicinal Plants Used for the Treatment of Diabetes in Eritrea. ScientificWorldJournal, 2016
  66. Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015. BMC Genomics, 2016
  67. Antihyperglycemic effect of thymoquinone and oleuropein, on streptozotocin-induced diabetes mellitus in experimental animals. Pharmacogn Mag, 2015
  68. Antimicrobial activity of Nigella sativa L. seed oil against multi-drug resistant Staphylococcus aureus isolated from diabetic wounds. Pak J Pharm Sci, 2015
  69. Nigella sativa: A potential natural protective agent against cardiac dysfunction in patients with type 2 diabetes mellitus. J Family Community Med, 2015
  70. Alternative supplement for enhancement of reproductive health and metabolic profile among perimenopausal women: a novel role of Nigella sativa. Iran J Basic Med Sci, 2014
  71. Anti-diabetic activity of different oils through their effect on arylsulfatases. J Diabetes Metab Disord, 2014
  72. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J Ethnopharmacol, 2014
  73. Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus. Evid Based Complement Alternat Med, 2014
  74. Nigella sativa is a safe herbal product. J Integr Med, 2014
  75. Protective Effects of Nigella sativa on Metabolic Syndrome in Menopausal Women. Adv Pharm Bull, 2014
  76. The effect of black seed (Nigella sativa) extract on FOXO3 expression in HepG2 cells. Phytother Res, 2014
  77. A systematic review of anti-obesity medicinal plants - an update. J Diabetes Metab Disord, 2013
  78. Effects of Nigella sativa on outcome of hepatitis C in Egypt. World J Gastroenterol, 2013
  79. In Vitro Evaluations of Cytotoxicity of Eight Antidiabetic Medicinal Plants and Their Effect on GLUT4 Translocation. Evid Based Complement Alternat Med, 2013
  80. Favorable impact of Nigella sativa seeds on lipid profile in type 2 diabetic patients. J Family Community Med, 2012
  81. Nigella sativa: A Potential Antiosteoporotic Agent. Evid Based Complement Alternat Med, 2012
  82. Self-reported use of complementary and alternative medicine (CAM) products in topical treatment of diabetic foot disorders by diabetic patients in Jeddah, Western Saudi Arabia. BMC Res Notes, 2010
  83. Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells. Diabetes Obes Metab, 2010
  84. Emerging clinical and therapeutic applications of Nigella sativa in gastroenterology. World J Gastroenterol, 2009
  85. Thymoquinone protects renal tubular cells against tubular injury. Cell Biochem Funct, 2008
  86. Effect of Nigella sativa oil on various clinical and biochemical parameters of insulin resistance syndrome. Int J Diabetes Dev Ctries, 2008
  87. Ethnopharmacological survey of plants used in the traditional treatment of hypertension and diabetes in south-eastern Morocco (Errachidia province). J Ethnopharmacol, 2007
  88. Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2. Int J Environ Res Public Health, 2005
  89. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomed Sci Instrum, 2003
  90. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J, 2002
Reviews 82
  1. Translational Pharmaceutical Perspectives on Quinones as Antioxidant and Antidiabetic Agents in Diabetes and Its Complications. Pharmaceutics, 2026
  2. Glycation of Salivary Aldehyde Dehydrogenase: Emerging Molecular Mechanisms and Clinical Implications in Oral Disease. Life (Basel), 2026
  3. Potential Benefits of Nigella sativa (Black Seeds) in the Management of Coronavirus Disease-2019 (COVID-19)-Associated New-Onset Diabetes Mellitus (NODM): An Overview. Infect Disord Drug Targets, 2026
  4. Analysis of Pharmacological Properties of Nigella sativa L. Bioactive Compounds and Their Therapeutic Relevance in the Management of Type 2 Diabetes Mellitus. Life (Basel), 2025
  5. Persian Medicinal Plants as Antidiabetic Agents: Mechanisms and Evidence from Bench to Bedside . Iran Biomed J, 2025
  6. Potential of Secondary Metabolite Compounds of Black Cumin Seeds (Nigella sativa L.) as Therapeutic Agents for Chronic Diseases. Drug Des Devel Ther, 2025
  7. Therapeutic efficacy of Nigella sativa and Ziziphus lotus: sustainable strategies for diabetes, antimicrobial resistance, and health treatment. Front Nutr, 2025
  8. Evidence-Based Human Clinical Trials on Antidiabetic Herbal Remedies Commonly Used in the Middle East. Sultan Qaboos Univ Med J, 2025
  9. An artificial intelligence-aided scoping review of medicinal plant research in the Fertile Crescent. Front Pharmacol, 2025
  10. Effects of Nigella sativa on VCAM-1 and ICAM-1: A systematic review of preclinical and clinical studies. J Cardiovasc Thorac Res, 2025
  11. A Comprehensive Review of the Antioxidant, Antimicrobial, and Therapeutic Efficacies of Black Cumin (Nigella sativa L.) Seed Oil and Its Thymoquinone. J Med Food, 2025
  12. Natural Products in the Clinical Management of Metabolic Syndrome. Handb Exp Pharmacol, 2025
  13. A Comprehensive Review of Moroccan Medicinal Plants for Diabetes Management. Diseases, 2024
  14. Thymoquinone: A comprehensive review of its potential role as a monotherapy for metabolic syndrome. Iran J Basic Med Sci, 2024
  15. Ameliorative Effects of Essential Oils on Diabetes Mellitus: A Review. Curr Top Med Chem, 2024
  16. Nigella sativa L. and its bioactive and nutraceutical components in the management of diabetic peripheral neuropathy. Inflammopharmacology, 2024
  17. Metabolic dysfunction-associated fatty liver disease: current therapeutic strategies. Front Nutr, 2024
  18. The Power of the Underutilized and Neglected Medicinal Plants and Herbs of the Middle East. Rev Recent Clin Trials, 2024
  19. Effects and mechanisms of anti-diabetic dietary natural products: an updated review. Food Funct, 2024
  20. Potential Pharmacological Applications of Nigella Seeds with a Focus on Nigella sativa and Its Constituents against Chronic Inflammatory Diseases: Progress and Future Opportunities. Plants (Basel), 2023
  21. Mechanism of the antidiabetic action of Nigella sativa and Thymoquinone: a review. Front Nutr, 2023
  22. Nigella sativa and its nano-mediated approach toward management of neurodegenerative disorders: A review. Ibrain, 2023
  23. A Review of the Potential Health Benefits of Nigella sativa on Obesity and Its Associated Complications. Plants (Basel), 2023
  24. The Efficacy of Herbs as Complementary and Alternative Therapy in Recovery and Clinical Outcome Among People with COVID-19: A Systematic Review, Meta-Analysis, and Meta-Regression. Ther Clin Risk Manag, 2023
  25. Effect of saffron, black seed, and their main constituents on inflammatory cytokine response (mainly TNF-α) and oxidative stress status: an aspect on pharmacological insights. Naunyn Schmiedebergs Arch Pharmacol, 2023
  26. Therapeutic application of natural products: NAD+ metabolism as potential target. Phytomedicine, 2023
  27. Nutraceuticals as Supportive Therapeutic Agents in Diabetes and Pancreatic Ductal Adenocarcinoma: A Systematic Review. Biology (Basel), 2023
  28. Plant Essential Oils as Healthy Functional Ingredients of Nutraceuticals and Diet Supplements: A Review. Molecules, 2023
  29. Synergistic Effects of Nigella sativa and Exercise on Diabetic Profiles: A Systematic Review. Diabetes Ther, 2023
  30. Nutraceutical activation of Sirt1: a review. Open Heart, 2022
  31. Potential health benefits of Nigella sativa on diabetes mellitus and its complications: A review from laboratory studies to clinical trials. Front Nutr, 2022
  32. A Narrative Review on Various Oil Extraction Methods, Encapsulation Processes, Fatty Acid Profiles, Oxidative Stability, and Medicinal Properties of Black Seed (Nigella sativa). Foods, 2022
  33. Nigella sativa supplementation improves cardiometabolic indicators in population with prediabetes and type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Front Nutr, 2022
  34. Complementary and alternative medicine for glycemic control of diabetes mellitus: A systematic review. J Public Health Res, 2022
  35. Is Nigella sativa an Effective Bodyweight Lowering Agent and a Mitigator of Obesity Risk? A Literature Review. Vasc Health Risk Manag, 2022
  36. Thymoquinone in Ocular Neurodegeneration: Modulation of Pathological Mechanisms via Multiple Pathways. Front Cell Neurosci, 2022
  37. Effectiveness of Medicinal Plants for Glycaemic Control in Type 2 Diabetes: An Overview of Meta-Analyses of Clinical Trials. Front Pharmacol, 2021
  38. Effects of Nigella sativa, Camellia sinensis, and Allium sativum as Food Additives on Metabolic Disorders, a Literature Review. Front Pharmacol, 2021
  39. Therapeutic Screening of Herbal Remedies for the Management of Diabetes. Molecules, 2021
  40. Antidiabetic Activity of Nigella Sativa (Black Seeds) and Its Active Constituent (Thymoquinone): A Review of Human and Experimental Animal Studies. Chonnam Med J, 2021
  41. Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review. Int J Nanomedicine, 2021
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Other conditions Black seed oil has been studied for

Checked against PubMed on 2026-10-28. Everything we know about Black seed oil