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13 findings across 5 remedies and 10 conditions
- Berberine and blood sugar and type 2 diabetes4/5 ModerateBased on the evidence, berberine lowers blood sugar modestly in type 2 diabetes, about half a point of HbA1c in pooled trials, though most trials are small, short and from China.
- Berberine and cholesterol and blood fats4/5 ModerateBased on the evidence, berberine lowers LDL cholesterol and triglycerides by a small amount, though most trials were small, short, from China and judged at high risk of bias.
- Turmeric and arthritis pain (osteoarthritis and rheumatoid arthritis)4/5 ModerateBased on the evidence, turmeric and curcumin extracts modestly ease knee osteoarthritis pain in short trials, but most trials are small, short, test branded products and are rated low quality.
- Turmeric and depression4/5 ModerateBased on the evidence, curcumin added to usual care modestly lowers depression scores in short randomized trials, though the trials are small and their quality is rated low.
- Berberine and body weight3/5 LimitedSmall or mixed human studies suggest berberine may trim body weight by about a kilogram, but results disagree and the largest recent trial found no loss of belly fat.
- Fenbendazole and intestinal worms3/5 LimitedSmall or mixed human studies suggest fenbendazole can clear roundworm and reduce hookworm and whipworm in people, based on 1970s trials of a form that was never approved for human use.
- IP6 and chemotherapy side effects3/5 LimitedSmall or mixed human studies suggest IP6 may ease chemotherapy side effects and protect quality of life, based on two small trials in breast cancer patients.
- IP6 and heart-valve and artery calcification3/5 LimitedSmall or mixed human studies suggest IP6 may slow calcium build-up in heart valves and arteries, but the trials used an intravenous drug form, not oral supplements.
- IP6 and kidney stones3/5 LimitedSmall or mixed human studies suggest IP6 in the diet may lower the risk of kidney stones, but the results disagree and no trial has tested it on stones.
- Turmeric and cancer3/5 LimitedSmall or mixed human studies suggest curcumin may help some chemotherapy regimens or ease treatment side effects, but controlled trials on tumors disagree and the strongest positive one used an intravenous form.
- Fenbendazole and cancer2/5 PreliminaryAnimal studies and case reports suggest fenbendazole has some anti-cancer activity in cells and mice, but no human trial has tested it, the only PubMed case series of remissions was retracted, and most published human cases describe liver injury.
- IP6 and cancer2/5 PreliminaryAnimal studies and case reports suggest IP6 may act against several kinds of cancer, but no controlled human trial has measured its effect on tumors.
- Ivermectin and cancer2/5 PreliminaryAnimal studies and case reports suggest ivermectin slows cancer cells and tumors in mice, but no controlled trial in people with cancer has reported results, the largest human report was retracted, and published cases include serious poisoning.
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